Methanesulfonic acid,1,1,1-trifluoro-, Methyl ester
methyl trifluoromethanesulphonate
CAS: 333-27-7
Molecular Formula: C2H3F3O3S
Methanesulfonic acid,1,1,1-trifluoro-, Methyl ester - Names and Identifiers
Methanesulfonic acid,1,1,1-trifluoro-, Methyl ester - Physico-chemical Properties
| Molecular Formula | C2H3F3O3S |
| Molar Mass | 164.1 |
| Density | 1.45g/mLat 25°C(lit.) |
| Boling Point | 94-99°C(lit.) |
| Flash Point | 101°F |
| Vapor Presure | 49.662mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.450 |
| Color | Clear colorless to yellow |
| BRN | 774772 |
| Storage Condition | 2-8°C |
| Sensitive | Air Sensitive |
| Refractive Index | n20/D 1.326(lit.) |
| Physical and Chemical Properties | Boiling point 94-99°C(lit.) density 1.45g/mL at 25°C(lit.) refractive index n20/D 1.326(lit.) flash point 101 °F storage conditions 0-6°C |
Methanesulfonic acid,1,1,1-trifluoro-, Methyl ester - Risk and Safety
| Risk Codes | R10 - Flammable R34 - Causes burns R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S16 - Keep away from sources of ignition. |
| UN IDs | UN 2920 8/PG 2 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| TSCA | T |
| HS Code | 29049020 |
| Hazard Note | Highly Toxic/Corrosive |
| Hazard Class | 3.2 |
| Packing Group | III |
Methanesulfonic acid,1,1,1-trifluoro-, Methyl ester - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Overview | Methyl trifluoromethanesulfonate is a very useful class of trifluoromethanesulfonate reagents in organic synthesis, commonly used as alkylation reagents. The strong electron-withdrawing ability and reactivity of trifluoromethanesulfonyl groups of trifluoromethanesulfonate compounds are much higher than those of conventional alkylating reagents, such as chlorides or alkyl sulfonates. Because these compounds are very active, only methyl trifluoromethanesulfonate is relatively stable. Other trifluoromethanesulfonate is prone to side reactions such as elimination and rearrangement, which need to be combined and post-treated under mild conditions. |
| preparation | synthesis of methyl trifluoromethanesulfonate: under ice bath, trimethyl orthoformate (3.18g,30mmol) is slowly added to trifluoromethanesulfonate anhydride (8.47g,30mmol), transferred to 25 ℃ for reaction, nuclear magnetic resonance monitoring for 15 minutes, after reaction, 9.74g of colorless liquid of methyl trifluoromethanesulfonate is obtained by distillation under reduced pressure, with a yield of 99%. |
| Preparation method of methyl trifluoromethanesulfonate | Trifluoromethanesulfonic acid and potassium carbonate first form a salt, and react with dimethyl sulfate in DMF or DMSO, Then add water to wash and distill, or trifluoromethanesulfonic acid and methanol directly esterify. |
| uses | intermediates in organic synthesis and pharmaceutical synthesis, monomethylation reagents. |
Last Update：2024-04-10 22:29:15
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